GO.ID Description p.Val FDR Phenotype Genes GO:0048015 phosphatidylinositol-mediated signaling 5.63e-16 5.63e-16 1 HGF,FGFR2,FGFR3,PIK3CG,GATA3,PIK3CA,FLT3,SOX9,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,NF1,MTOR GO:0048017 inositol lipid-mediated signaling 6.25e-16 6.25e-16 1 HGF,FGFR2,FGFR3,PIK3CG,GATA3,PIK3CA,FLT3,SOX9,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,NF1,MTOR GO:0048732 gland development 6.48e-16 6.48e-16 1 HGF,FGFR2,GATA3,FBXW7,SOX9,TBX3,BRCA2,AKT1,ARID5B,ARHGAP35,ELF3,AR,ERBB4,WT1,NF1,CEBPA GO:0014065 phosphatidylinositol 3-kinase signaling 1.91e-14 1.91e-14 1 HGF,FGFR2,FGFR3,PIK3CG,GATA3,PIK3CA,FLT3,SOX9,PDGFRA,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,NF1 REAC:5654695 PI-3K cascade:FGFR2 5.58e-14 5.58e-14 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR REAC:5654689 PI-3K cascade:FGFR1 5.58e-14 5.58e-14 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR REAC:1250342 PI3K events in ERBB4 signaling 5.58e-14 5.58e-14 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR REAC:1257604 PIP3 activates AKT signaling 5.58e-14 5.58e-14 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR REAC:5654720 PI-3K cascade:FGFR4 5.58e-14 5.58e-14 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR REAC:5654710 PI-3K cascade:FGFR3 5.58e-14 5.58e-14 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR REAC:198203 PI3K/AKT activation 8.28e-14 8.28e-14 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR REAC:180292 GAB1 signalosome 8.28e-14 8.28e-14 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR REAC:1168372 Downstream signaling events of B Cell Receptor (BCR) 4.11e-13 4.11e-13 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR,NRAS REAC:2219528 PI3K/AKT Signaling in Cancer 3.53e-12 3.53e-12 1 HGF,FGFR2,FGFR3,CDKN1B,PIK3CA,CDKN1A,PDGFRA,AKT1,PIK3R1,EGFR,KIT,ERBB4,PTPN11,MTOR GO:1902806 regulation of cell cycle G1/S phase transition 5.30e-12 5.30e-12 1 EP300,FBXW7,CCND1,CDKN1B,CDKN1A,RB1,TP53,AKT1,EGFR,TAF1,ATM,PTEN,NPM1,CHEK2 GO:0046777 protein autophosphorylation 7.39e-12 7.39e-12 1 FGFR2,FGFR3,STK11,FLT3,PDGFRA,ACVR1B,AKT1,EGFR,TAF1,ATM,KIT,CDK12,ATR,ERBB4,CHEK2,LRRK2,MTOR REAC:1236394 Signaling by ERBB4 4.12e-11 4.12e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,NCOR1,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:1433557 Signaling by SCF-KIT 4.82e-11 4.82e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 5.02e-11 5.02e-11 1 HGF,FGFR2,FGFR3,PIK3CA,FLT3,SOX9,PDGFRA,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11 REAC:5654696 Downstream signaling of activated FGFR2 5.73e-11 5.73e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:5654716 Downstream signaling of activated FGFR4 5.73e-11 5.73e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:5654708 Downstream signaling of activated FGFR3 5.73e-11 5.73e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:5654743 Signaling by FGFR4 6.80e-11 6.80e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:5654687 Downstream signaling of activated FGFR1 6.80e-11 6.80e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:5654741 Signaling by FGFR3 7.19e-11 7.19e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:5654736 Signaling by FGFR1 9.00e-11 9.00e-11 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,BRAF,PTEN,ERBB4,PTPN11,NF1,MTOR,NRAS GO:0051052 regulation of DNA metabolic process 1.23e-10 1.23e-10 1 BRCA1,HGF,POLQ,SMC1A,ATRX,STAG2,PPP2R1A,SMC3,FBXW7,PDGFRA,TP53,AKT1,EGFR,CDKN2A,ATM,AXIN2,ATR,NPM1,CHEK2 REAC:199418 Negative regulation of the PI3K/AKT network 1.82e-10 1.82e-10 1 HGF,FGFR2,FGFR3,PPP2R1A,PIK3CA,PDGFRA,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11 REAC:2730905 Role of LAT2/NTAL/LAB on calcium mobilization 1.95e-10 1.95e-10 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR GO:0044843 cell cycle G1/S phase transition 2.57e-10 2.57e-10 1 EP300,FBXW7,CCND1,CDKN1B,CDKN2C,CDKN1A,ACVR1B,RB1,TP53,AKT1,EGFR,TAF1,CDKN2A,ATM,PTEN,NPM1,CHEK2 GO:0048762 mesenchymal cell differentiation 3.05e-10 3.05e-10 1 HGF,EPHA3,FGFR2,EZH2,SOX9,FOXA2,FOXA1,SMAD4,NOTCH1,TGFBR2,CTNNB1,AXIN2,SMAD2,ERBB4 GO:0060485 mesenchyme development 3.36e-10 3.36e-10 1 HGF,EPHA3,FGFR2,EZH2,SOX9,FOXA2,FOXA1,SMAD4,NOTCH1,TGFBR2,CTNNB1,AXIN2,SMAD2,ERBB4,WT1 GO:0040008 regulation of growth 3.40e-10 3.40e-10 1 FGFR2,FGFR3,PPP2R1A,CDKN1B,STK11,CDKN1A,ACVR1B,TP53,SMAD4,AKT1,EGFR,CDKN2A,NOTCH1,BAP1,SOX17,PTEN,ERBB4,WT1,H3F3C REAC:983705 Signaling by the B Cell Receptor (BCR) 3.87e-10 3.87e-10 1 HGF,FGFR2,FGFR3,PPP2R1A,CDKN1B,PIK3CA,CDKN1A,KRAS,PDGFRA,TP53,AKT1,PIK3R1,EGFR,KIT,PTEN,ERBB4,PTPN11,MTOR,NRAS GO:0010948 negative regulation of cell cycle process 5.41e-10 5.41e-10 1 BRCA1,SMC1A,ATRX,EP300,STAG2,SMC3,FBXW7,CCND1,CDKN1B,CDKN1A,APC,RB1,TP53,ATM,PTEN,NPM1,CHEK2 GO:0045787 positive regulation of cell cycle 6.56e-10 6.56e-10 1 BRCA1,FGFR2,ATRX,EP300,CCND1,CDKN1B,CDKN1A,FOXA1,TBX3,RB1,TP53,AKT1,EGFR,ATM,NPM1,CHEK2 GO:2000045 regulation of G1/S transition of mitotic cell cycle 7.89e-10 7.89e-10 1 EP300,CCND1,CDKN1B,CDKN1A,RB1,TP53,AKT1,EGFR,ATM,PTEN,NPM1,CHEK2 GO:0042326 negative regulation of phosphorylation 1.12e-09 1.12e-09 1 MECOM,PPP2R1A,CDKN1B,CDKN2C,CDKN1A,FOXA2,APC,TLR4,RB1,NCOR1,SMAD4,AKT1,CDKN2A,PTEN,CRIPAK,NPM1,LRRK2,NF1,CEBPA REAC:6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 1.59e-09 1.59e-09 1 HGF,FGFR2,FGFR3,PPP2R1A,PIK3CA,PDGFRA,AKT1,PIK3R1,EGFR,KIT,ERBB4,PTPN11 REAC:8848021 Signaling by PTK6 1.81e-09 1.81e-09 1 CCND1,CDKN1B,KRAS,AKT1,EGFR,ARHGAP35,ERBB4,LRRK2,NF1,NRAS GO:0016049 cell growth 1.82e-09 1.82e-09 1 PPP2R1A,CDKN1B,STK11,USP9X,CDKN1A,SOX9,ACVR1B,TP53,SMAD4,AKT1,EGFR,CDKN2A,BAP1,SOX17,AR,WT1,H3F3C,MTOR GO:1901987 regulation of cell cycle phase transition 2.01e-09 2.01e-09 1 EP300,FBXW7,CCND1,CDKN1B,CDKN1A,APC,RB1,TP53,AKT1,EGFR,TAF1,CDKN2A,ATM,PTEN,NPM1,CHEK2 REAC:112399 IRS-mediated signalling 3.62e-09 3.62e-09 1 HGF,FGFR2,FGFR3,PPP2R1A,STK11,PIK3CA,KRAS,PDGFRA,AKT1,PIK3R1,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,MTOR,NRAS GO:0001837 epithelial to mesenchymal transition 4.40e-09 4.40e-09 1 HGF,EPHA3,EZH2,SOX9,FOXA2,FOXA1,SMAD4,NOTCH1,TGFBR2,CTNNB1,AXIN2,SMAD2 REAC:2428928 IRS-related events triggered by IGF1R 4.54e-09 4.54e-09 1 HGF,FGFR2,FGFR3,PPP2R1A,STK11,PIK3CA,KRAS,PDGFRA,AKT1,PIK3R1,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:74751 Insulin receptor signalling cascade 4.54e-09 4.54e-09 1 HGF,FGFR2,FGFR3,PPP2R1A,STK11,PIK3CA,KRAS,PDGFRA,AKT1,PIK3R1,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:2428924 IGF1R signaling cascade 4.54e-09 4.54e-09 1 HGF,FGFR2,FGFR3,PPP2R1A,STK11,PIK3CA,KRAS,PDGFRA,AKT1,PIK3R1,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,MTOR,NRAS REAC:2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) 4.80e-09 4.80e-09 1 HGF,FGFR2,FGFR3,PPP2R1A,STK11,PIK3CA,KRAS,PDGFRA,AKT1,PIK3R1,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,MTOR,NRAS GO:0007050 cell cycle arrest 6.05e-09 6.05e-09 1 BRCA1,EP300,CCND1,CDKN1B,STK11,CDKN1A,APC,RB1,TP53,CDKN2A,ATM,NPM1,CHEK2,MTOR REAC:74752 Signaling by Insulin receptor 1.66e-08 1.66e-08 1 HGF,FGFR2,FGFR3,PPP2R1A,STK11,PIK3CA,KRAS,PDGFRA,AKT1,PIK3R1,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,MTOR,NRAS GO:0000082 G1/S transition of mitotic cell cycle 2.03e-08 2.03e-08 1 EP300,CCND1,CDKN1B,CDKN2C,CDKN1A,ACVR1B,RB1,TP53,AKT1,EGFR,CDKN2A,ATM,PTEN,NPM1,CHEK2 GO:0000075 cell cycle checkpoint 2.15e-08 2.15e-08 1 BRCA1,SMC1A,EP300,CCND1,CDKN1B,CDKN1A,APC,RB1,TP53,AKT1,ATM,ATR,NPM1,CHEK2 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 2.44e-08 2.44e-08 1 EP300,CCND1,CDKN1B,CDKN1A,RB1,TP53,ATM,PTEN,NPM1,CHEK2 GO:0007507 heart development 3.08e-08 3.08e-08 1 FGFR2,GATA3,SOX9,PDGFRA,SMAD4,EGFR,NOTCH1,TGFBR2,SOX17,CTNNB1,PTEN,ERBB4,PTPN11,WT1,NF1 GO:1902807 negative regulation of cell cycle G1/S phase transition 3.11e-08 3.11e-08 1 EP300,CCND1,CDKN1B,CDKN1A,RB1,TP53,ATM,PTEN,NPM1,CHEK2 GO:0030879 mammary gland development 3.21e-08 3.21e-08 1 FGFR2,GATA3,TBX3,BRCA2,AKT1,ARHGAP35,ELF3,ERBB4 REAC:2219530 Constitutive Signaling by Aberrant PI3K in Cancer 3.26e-08 3.26e-08 1 HGF,FGFR2,FGFR3,PIK3CA,PDGFRA,PIK3R1,EGFR,KIT,ERBB4,PTPN11 REAC:4420097 VEGFA-VEGFR2 Pathway 4.25e-08 4.25e-08 1 HGF,FGFR2,FGFR3,PPP2R1A,PIK3CA,KRAS,PDGFRA,AKT1,PIK3R1,EGFR,KIT,BRAF,CTNNB1,ERBB4,NF1,MTOR,NRAS GO:0045926 negative regulation of growth 4.54e-08 4.54e-08 1 FGFR3,PPP2R1A,CDKN1B,STK11,CDKN2C,CDKN1A,ACVR1B,TP53,SMAD4,CDKN2A,SOX17,PTEN,WT1 GO:0010717 regulation of epithelial to mesenchymal transition 4.66e-08 4.66e-08 1 EPHA3,EZH2,FOXA2,FOXA1,SMAD4,NOTCH1,TGFBR2,CTNNB1,AXIN2,SMAD2 REAC:194138 Signaling by VEGF 6.19e-08 6.19e-08 1 HGF,FGFR2,FGFR3,PPP2R1A,PIK3CA,KRAS,PDGFRA,AKT1,PIK3R1,EGFR,KIT,BRAF,CTNNB1,ERBB4,NF1,MTOR,NRAS GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 6.84e-08 6.84e-08 1 CCND1,CDKN1B,CDKN2C,CDKN1A,APC,AKT1,EGFR,CDKN2A,PTEN,CEBPA REAC:5637812 Signaling by EGFRvIII in Cancer 6.99e-08 6.99e-08 1 PIK3CA,KRAS,PIK3R1,EGFR,NRAS REAC:5637810 Constitutive Signaling by EGFRvIII 6.99e-08 6.99e-08 1 PIK3CA,KRAS,PIK3R1,EGFR,NRAS GO:1904029 regulation of cyclin-dependent protein kinase activity 9.22e-08 9.22e-08 1 CCND1,CDKN1B,CDKN2C,CDKN1A,APC,AKT1,EGFR,CDKN2A,PTEN,CEBPA GO:1901990 regulation of mitotic cell cycle phase transition 9.80e-08 9.80e-08 1 EP300,CCND1,CDKN1B,CDKN1A,APC,RB1,TP53,AKT1,EGFR,CDKN2A,ATM,PTEN,NPM1,CHEK2 GO:0016570 histone modification 1.05e-07 1.05e-07 1 BRCA1,ATRX,EP300,EZH2,KDM5C,BRCA2,TP53,SMAD4,KDM6A,BAP1,NSD1,CTNNB1,TET2,SIN3A,ASXL1,TBL1XR1,SETD2 GO:0042770 signal transduction in response to DNA damage 1.20e-07 1.20e-07 1 BRCA1,SMC1A,ATRX,EP300,CDKN1B,CDKN1A,TP53,ATM,ATR,NPM1,CHEK2 GO:0033157 regulation of intracellular protein transport 1.43e-07 1.43e-07 1 CDH1,KEAP1,FBXW7,TLR4,TP53,SMAD4,PIK3R1,EGFR,U2AF1,BAP1,ERBB4,SETD2,LRRK2,NF1 GO:0016569 covalent chromatin modification 2.00e-07 2.00e-07 1 BRCA1,ATRX,EP300,EZH2,KDM5C,BRCA2,TP53,SMAD4,KDM6A,BAP1,NSD1,CTNNB1,TET2,SIN3A,ASXL1,TBL1XR1,SETD2 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity 2.28e-07 2.28e-07 1 KEAP1,EP300,FOXA2,FOXA1,TLR4,RB1,AKT1,TAF1,CDKN2A,ARID5B,KIT,CTNNB1,AR,PTEN,NPM1 GO:0045930 negative regulation of mitotic cell cycle 2.54e-07 2.54e-07 1 SMC1A,ATRX,EP300,CCND1,CDKN1B,CDKN1A,APC,RB1,TP53,ATM,CTNNB1,PTEN,NPM1,CHEK2 REAC:5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer 2.69e-07 2.69e-07 1 PIK3CA,KRAS,PIK3R1,EGFR,NRAS REAC:1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 2.69e-07 2.69e-07 1 PIK3CA,KRAS,PIK3R1,EGFR,NRAS REAC:1643713 Signaling by EGFR in Cancer 2.69e-07 2.69e-07 1 PIK3CA,KRAS,PIK3R1,EGFR,NRAS GO:0030330 DNA damage response, signal transduction by p53 class mediator 3.46e-07 3.46e-07 1 BRCA1,ATRX,EP300,CDKN1B,CDKN1A,TP53,ATM,ATR,NPM1,CHEK2 GO:0033673 negative regulation of kinase activity 3.66e-07 3.66e-07 1 CDKN1B,APC,RB1,AKT1,CDKN2A,PTEN,CRIPAK,NPM1,NF1,CEBPA GO:0071407 cellular response to organic cyclic compound 3.68e-07 3.68e-07 1 BRCA1,CDH1,EP300,ARID1A,FOXA1,RB1,NCOR1,EGFR,TAF1,CTNNB1,AR,SMAD2,CRIPAK,NPM1,WT1,LRRK2 REAC:1227986 Signaling by ERBB2 4.89e-07 4.89e-07 1 PIK3CA,KRAS,AKT1,PIK3R1,EGFR,ERBB4,NRAS GO:0034968 histone lysine methylation 5.16e-07 5.16e-07 1 BRCA1,ATRX,EZH2,SMAD4,KDM6A,NSD1,CTNNB1,TET2,SETD2 GO:0006469 negative regulation of protein kinase activity 5.44e-07 5.44e-07 1 APC,RB1,AKT1,CDKN2A,PTEN,CRIPAK,NPM1,NF1,CEBPA GO:0001558 regulation of cell growth 5.72e-07 5.72e-07 1 PPP2R1A,CDKN1B,STK11,CDKN2C,CDKN1A,ACVR1B,TP53,SMAD4,AKT1,EGFR,CDKN2A,BAP1,SOX17,WT1,H3F3C GO:0006275 regulation of DNA replication 5.89e-07 5.89e-07 1 SMC1A,ATRX,STAG2,PPP2R1A,SMC3,FBXW7,PDGFRA,EGFR,ATR,CHEK2 REAC:5633007 Regulation of TP53 Activity 6.50e-07 6.50e-07 1 BRCA1,EP300,PPP2R1A,STK11,TP53,AKT1,TAF1,CDKN2A,ATM,ATR,CHEK2,MTOR GO:0030308 negative regulation of cell growth 6.78e-07 6.78e-07 1 PPP2R1A,CDKN1B,STK11,CDKN2C,CDKN1A,ACVR1B,TP53,SMAD4,CDKN2A,SOX17,WT1 GO:0072331 signal transduction by p53 class mediator 7.05e-07 7.05e-07 1 BRCA1,ATRX,EP300,CDKN1B,STK11,CDKN1A,TP53,AKT1,TAF1,ATM,ATR,NPM1,CHEK2 REAC:8853334 Signaling by FGFR3 fusions in cancer 7.17e-07 7.17e-07 1 FGFR3,PIK3CA,KRAS,PIK3R1,NRAS GO:0038127 ERBB signaling pathway 8.04e-07 8.04e-07 1 FBXW7,PIK3CA,SOX9,KRAS,AKT1,PIK3R1,EGFR,ERBB4,NRAS GO:0006260 DNA replication 8.59e-07 8.59e-07 1 BRCA1,POLQ,SMC1A,ATRX,STAG2,PPP2R1A,SMC3,FBXW7,PDGFRA,BRCA2,EGFR,ATM,ATR,CHEK2 REAC:512988 Interleukin-3, 5 and GM-CSF signaling 9.43e-07 9.43e-07 1 HGF,FGFR2,FGFR3,PPP2R1A,PIK3CA,KRAS,PDGFRA,PIK3R1,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS REAC:912526 Interleukin receptor SHC signaling 9.84e-07 9.84e-07 1 HGF,FGFR2,FGFR3,PPP2R1A,PIK3CA,KRAS,PDGFRA,PIK3R1,EGFR,KIT,BRAF,ERBB4,NF1,NRAS GO:0044786 cell cycle DNA replication 9.93e-07 9.93e-07 1 SMC1A,ATRX,STAG2,SMC3,FBXW7,BRCA2,CHEK2 GO:0007568 aging 1.05e-06 1.05e-06 1 CDKN1A,TBX3,TP53,CDKN2A,ATM,ATR,NPM1,CHEK2,LRRK2 GO:0001933 negative regulation of protein phosphorylation 1.10e-06 1.10e-06 1 MECOM,PPP2R1A,APC,TLR4,RB1,NCOR1,SMAD4,AKT1,CDKN2A,PTEN,CRIPAK,NPM1,LRRK2,NF1,CEBPA GO:0051348 negative regulation of transferase activity 1.11e-06 1.11e-06 1 CDKN1B,APC,RB1,TP53,AKT1,CDKN2A,PTEN,CRIPAK,NPM1,NF1,CEBPA GO:0007093 mitotic cell cycle checkpoint 1.18e-06 1.18e-06 1 SMC1A,EP300,CCND1,CDKN1B,CDKN1A,APC,RB1,TP53,ATM,NPM1,CHEK2 GO:0033044 regulation of chromosome organization 1.33e-06 1.33e-06 1 BRCA1,ATRX,CTCF,APC,RB1,TP53,SMAD4,ATM,RAD21,NSD1,CTNNB1,AXIN2,SIN3A,ATR REAC:451927 Interleukin-2 signaling 1.40e-06 1.40e-06 1 HGF,FGFR2,FGFR3,PPP2R1A,PIK3CA,KRAS,PDGFRA,PIK3R1,EGFR,KIT,BRAF,ERBB4,NF1,NRAS GO:0071214 cellular response to abiotic stimulus 1.61e-06 1.61e-06 1 MAP2K4,MAP3K1,EP300,GATA3,STK11,CDKN1A,SOX9,TLR4,TP53,TAF1,ATM,ATR GO:1903533 regulation of protein targeting 1.62e-06 1.62e-06 1 CDH1,KEAP1,FBXW7,TLR4,SMAD4,PIK3R1,EGFR,U2AF1,BAP1,ERBB4,LRRK2,NF1 REAC:6804757 Regulation of TP53 Degradation 1.67e-06 1.67e-06 1 PPP2R1A,TP53,AKT1,CDKN2A,ATM,CHEK2,MTOR GO:0007173 epidermal growth factor receptor signaling pathway 1.83e-06 1.83e-06 1 FBXW7,PIK3CA,SOX9,KRAS,AKT1,PIK3R1,EGFR,NRAS GO:0007059 chromosome segregation 1.83e-06 1.83e-06 1 BRCA1,SMC1A,ATRX,STAG2,CTCF,ERCC2,PPP2R1A,SMC3,FBXW7,APC,RB1,ATM,RAD21,CTNNB1,AXIN2 GO:0090399 replicative senescence 1.84e-06 1.84e-06 1 TP53,CDKN2A,ATM,ATR,CHEK2 GO:0018022 peptidyl-lysine methylation 1.92e-06 1.92e-06 1 BRCA1,ATRX,EZH2,SMAD4,KDM6A,NSD1,CTNNB1,TET2,SETD2 GO:0009314 response to radiation 1.96e-06 1.96e-06 1 BRCA1,SMC1A,EP300,GATA3,CCND1,STK11,CDKN1A,TP53,AKT1,EGFR,TAF1,ATM,ATR,NF1 REAC:6806003 Regulation of TP53 Expression and Degradation 2.05e-06 2.05e-06 1 PPP2R1A,TP53,AKT1,CDKN2A,ATM,CHEK2,MTOR GO:0007569 cell aging 2.31e-06 2.31e-06 1 CDKN1A,TBX3,TP53,CDKN2A,ATM,ATR,NPM1,CHEK2 GO:1901991 negative regulation of mitotic cell cycle phase transition 3.19e-06 3.19e-06 1 EP300,CCND1,CDKN1B,CDKN1A,APC,RB1,TP53,ATM,PTEN,NPM1,CHEK2 GO:0044819 mitotic G1/S transition checkpoint 3.27e-06 3.27e-06 1 EP300,CCND1,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0031571 mitotic G1 DNA damage checkpoint 3.27e-06 3.27e-06 1 EP300,CCND1,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0046822 regulation of nucleocytoplasmic transport 3.38e-06 3.38e-06 1 CDH1,KEAP1,TLR4,TP53,SMAD4,PIK3R1,EGFR,ERBB4,SETD2,NF1 REAC:5655291 Signaling by FGFR4 in disease 3.42e-06 3.42e-06 1 PIK3CA,KRAS,PIK3R1,NRAS GO:0044783 G1 DNA damage checkpoint 3.68e-06 3.68e-06 1 EP300,CCND1,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0071156 regulation of cell cycle arrest 3.75e-06 3.75e-06 1 BRCA1,EP300,CCND1,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0007063 regulation of sister chromatid cohesion 4.05e-06 4.05e-06 1 ATRX,CTCF,RB1,RAD21,CTNNB1,AXIN2 GO:1901988 negative regulation of cell cycle phase transition 4.26e-06 4.26e-06 1 EP300,CCND1,CDKN1B,CDKN1A,APC,RB1,TP53,ATM,PTEN,NPM1,CHEK2 GO:0001655 urogenital system development 4.41e-06 4.41e-06 1 FGFR2,GATA3,SOX9,PDGFRA,SOX17,CTNNB1,AR,WT1,LRRK2,NF1 GO:0016579 protein deubiquitination 4.44e-06 4.44e-06 1 BRCA1,KEAP1,EP300,GATA3,USP9X,APC,TP53,SMAD4,BAP1,AXIN2,AR,ASXL1,PTEN,SMAD2 GO:0043525 positive regulation of neuron apoptotic process 4.69e-06 4.69e-06 1 FBXW7,TP53,CTNNB1,NF1 GO:0038128 ERBB2 signaling pathway 5.27e-06 5.27e-06 1 PIK3CA,KRAS,PIK3R1,EGFR,ERBB4,NRAS GO:0010718 positive regulation of epithelial to mesenchymal transition 5.79e-06 5.79e-06 1 EZH2,SMAD4,NOTCH1,TGFBR2,CTNNB1,AXIN2,SMAD2 GO:0009411 response to UV 6.05e-06 6.05e-06 1 EP300,ERCC2,CCND1,STK11,CDKN1A,TP53,AKT1,EGFR,TAF1,ATR GO:0016571 histone methylation 6.70e-06 6.70e-06 1 BRCA1,ATRX,EZH2,SMAD4,KDM6A,NSD1,CTNNB1,TET2,SETD2 GO:0000077 DNA damage checkpoint 6.84e-06 6.84e-06 1 BRCA1,EP300,CCND1,CDKN1B,CDKN1A,TP53,ATM,ATR,NPM1,CHEK2 GO:0070371 ERK1 and ERK2 cascade 7.10e-06 7.10e-06 1 FGFR2,FGFR3,FBXW7,SOX9,PDGFRA,TLR4,SMAD4,EGFR,BRAF,PTEN,ERBB4 GO:0070646 protein modification by small protein removal 9.58e-06 9.58e-06 1 BRCA1,KEAP1,EP300,GATA3,USP9X,APC,TP53,SMAD4,BAP1,AXIN2,AR,ASXL1,PTEN,SMAD2 GO:0033045 regulation of sister chromatid segregation 9.77e-06 9.77e-06 1 ATRX,CTCF,APC,RB1,ATM,RAD21,CTNNB1,AXIN2 GO:0071158 positive regulation of cell cycle arrest 9.96e-06 9.96e-06 1 BRCA1,EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0071496 cellular response to external stimulus 1.02e-05 1.02e-05 1 MAP2K4,MAP3K1,CDKN1A,SOX9,FOXA2,TLR4,TP53,ARHGAP35,LRRK2,MTOR GO:0031647 regulation of protein stability 1.02e-05 1.02e-05 1 EP300,FBXW7,CDKN1A,KRAS,VHL,PIK3R1,TAF1,CDKN2A,SOX17,PTEN,CHEK2 GO:0090068 positive regulation of cell cycle process 1.07e-05 1.07e-05 1 BRCA1,ATRX,EP300,CCND1,CDKN1B,CDKN1A,RB1,TP53,ATM,NPM1,CHEK2 GO:0071396 cellular response to lipid 1.13e-05 1.13e-05 1 BRCA1,EPHA3,EP300,ARID1A,SOX9,FOXA1,TLR4,RB1,EGFR,TAF1,CTNNB1,AR,CRIPAK GO:0035265 organ growth 1.26e-05 1.26e-05 1 FGFR2,FGFR3,SOX9,NOTCH1,PTEN,ERBB4,WT1 REAC:3247509 Chromatin modifying enzymes 1.34e-05 1.34e-05 1 MECOM,EP300,EZH2,CCND1,ARID1A,DNMT3A,KDM5C,NCOR1,KDM6A,ARID5B,HIST1H2BD,PBRM1,NSD1,TBL1XR1,SETD2 REAC:4839726 Chromatin organization 1.34e-05 1.34e-05 1 MECOM,EP300,EZH2,CCND1,ARID1A,DNMT3A,KDM5C,NCOR1,KDM6A,ARID5B,HIST1H2BD,PBRM1,NSD1,TBL1XR1,SETD2 GO:0031570 DNA integrity checkpoint 1.35e-05 1.35e-05 1 BRCA1,EP300,CCND1,CDKN1B,CDKN1A,TP53,ATM,ATR,NPM1,CHEK2 GO:0030518 intracellular steroid hormone receptor signaling pathway 1.39e-05 1.39e-05 1 BRCA1,EP300,ARID1A,FOXA1,RB1,TAF1,CTNNB1,AR,CRIPAK GO:0032876 negative regulation of DNA endoreduplication 1.47e-05 1.47e-05 1 SMC1A,STAG2,SMC3,FBXW7 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity 1.55e-05 1.55e-05 1 EP300,FOXA1,TLR4,AKT1,TAF1,ARID5B,KIT,CTNNB1,AR,PTEN,NPM1 GO:1900180 regulation of protein localization to nucleus 1.72e-05 1.72e-05 1 CDH1,KEAP1,TLR4,SMAD4,AKT1,PIK3R1,EGFR,AXIN2,SIN3A,ERBB4,NF1 REAC:5654706 FRS-mediated FGFR3 signaling 1.82e-05 1.82e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS REAC:5654693 FRS-mediated FGFR1 signaling 1.82e-05 1.82e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS REAC:5654700 FRS-mediated FGFR2 signaling 1.82e-05 1.82e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS REAC:5654712 FRS-mediated FGFR4 signaling 1.82e-05 1.82e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS GO:0007062 sister chromatid cohesion 1.85e-05 1.85e-05 1 SMC1A,ATRX,STAG2,CTCF,SMC3,FBXW7,RB1,RAD21,CTNNB1,AXIN2 GO:0043401 steroid hormone mediated signaling pathway 1.89e-05 1.89e-05 1 BRCA1,EP300,ARID1A,FOXA1,RB1,TAF1,CTNNB1,AR,CRIPAK GO:0018108 peptidyl-tyrosine phosphorylation 2.17e-05 2.17e-05 1 HGF,FGFR2,FGFR3,FBXW7,FLT3,PDGFRA,TP53,EGFR,KIT,ERBB4 REAC:5684996 MAPK1/MAPK3 signaling 2.31e-05 2.31e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS GO:0051053 negative regulation of DNA metabolic process 2.35e-05 2.35e-05 1 POLQ,SMC1A,STAG2,SMC3,FBXW7,TP53,ATM,ATR,CHEK2 GO:0018212 peptidyl-tyrosine modification 2.42e-05 2.42e-05 1 HGF,FGFR2,FGFR3,FBXW7,FLT3,PDGFRA,TP53,EGFR,KIT,ERBB4 GO:1901216 positive regulation of neuron death 2.46e-05 2.46e-05 1 FBXW7,TP53,CTNNB1,NF1 REAC:2586552 Signaling by Leptin 2.54e-05 2.54e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS REAC:210993 Tie2 Signaling 3.13e-05 3.13e-05 1 PIK3CA,KRAS,PIK3R1,NRAS GO:0000819 sister chromatid segregation 3.14e-05 3.14e-05 1 SMC1A,ATRX,STAG2,CTCF,SMC3,FBXW7,APC,RB1,ATM,RAD21,CTNNB1,AXIN2 GO:2001252 positive regulation of chromosome organization 3.18e-05 3.18e-05 1 BRCA1,ATRX,RB1,TP53,SMAD4,ATM,RAD21,CTNNB1,SIN3A,ATR GO:0035295 tube development 3.33e-05 3.33e-05 1 FGFR2,GATA3,SOX9,PDGFRA,NOTCH1,KIT,TGFBR2,SOX17,CTNNB1,WT1,CEBPA GO:0050821 protein stabilization 3.37e-05 3.37e-05 1 EP300,FBXW7,CDKN1A,VHL,PIK3R1,TAF1,SOX17,PTEN,CHEK2 GO:0044773 mitotic DNA damage checkpoint 3.42e-05 3.42e-05 1 EP300,CCND1,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 REAC:448424 Interleukin-17 signaling 3.51e-05 3.51e-05 1 HGF,MAP2K4,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS REAC:2871796 FCERI mediated MAPK activation 3.64e-05 3.64e-05 1 HGF,MAP2K4,FGFR2,FGFR3,MAP3K1,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 3.75e-05 3.75e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0042692 muscle cell differentiation 3.80e-05 3.80e-05 1 FGFR2,SOX9,PDGFRA,TBX3,RB1,SMAD4,NOTCH1,KIT,CTNNB1,WT1 GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint 4.22e-05 4.22e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint 4.22e-05 4.22e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0072001 renal system development 4.40e-05 4.40e-05 1 FGFR2,GATA3,SOX9,PDGFRA,SOX17,CTNNB1,WT1,LRRK2,NF1 REAC:69236 G1 Phase 4.43e-05 4.43e-05 1 PPP2R1A,CCND1,CDKN1B,CDKN2C,CDKN1A,RB1,CDKN2A REAC:69231 Cyclin D associated events in G1 4.43e-05 4.43e-05 1 PPP2R1A,CCND1,CDKN1B,CDKN2C,CDKN1A,RB1,CDKN2A REAC:112412 SOS-mediated signalling 4.61e-05 4.61e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS REAC:179812 GRB2 events in EGFR signaling 4.61e-05 4.61e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS REAC:1250347 SHC1 events in ERBB4 signaling 4.61e-05 4.61e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS REAC:180336 SHC1 events in EGFR signaling 4.61e-05 4.61e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS REAC:5673001 RAF/MAP kinase cascade 4.61e-05 4.61e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint 4.74e-05 4.74e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:1902402 signal transduction involved in mitotic DNA damage checkpoint 4.74e-05 4.74e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint 4.74e-05 4.74e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0030521 androgen receptor signaling pathway 4.77e-05 4.77e-05 1 BRCA1,EP300,ARID1A,RB1,TAF1,CTNNB1,AR GO:2000104 negative regulation of DNA-dependent DNA replication 5.31e-05 5.31e-05 1 SMC1A,STAG2,SMC3,FBXW7,CHEK2 GO:2000677 regulation of transcription regulatory region DNA binding 5.34e-05 5.34e-05 1 GATA3,RB1,TAF1,NSD1,CTNNB1,SIN3A GO:0043550 regulation of lipid kinase activity 5.44e-05 5.44e-05 1 FGFR3,FLT3,PDGFRA,RB1,PIK3R1,KIT REAC:170984 ARMS-mediated activation 5.51e-05 5.51e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS REAC:187706 Signalling to p38 via RIT and RIN 5.51e-05 5.51e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS GO:0070372 regulation of ERK1 and ERK2 cascade 5.53e-05 5.53e-05 1 FGFR2,FGFR3,FBXW7,PDGFRA,TLR4,SMAD4,EGFR,BRAF,PTEN,ERBB4 REAC:170968 Frs2-mediated activation 5.76e-05 5.76e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS GO:0043276 anoikis 5.90e-05 5.90e-05 1 STK11,PIK3CA,AKT1,NOTCH1,MTOR GO:0072401 signal transduction involved in DNA integrity checkpoint 5.94e-05 5.94e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0072422 signal transduction involved in DNA damage checkpoint 5.94e-05 5.94e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0008156 negative regulation of DNA replication 6.06e-05 6.06e-05 1 SMC1A,STAG2,SMC3,FBXW7,ATR,CHEK2 GO:0001763 morphogenesis of a branching structure 6.26e-05 6.26e-05 1 HGF,FGFR2,SOX9,TGFBR2,CTNNB1,WT1,LRRK2 REAC:169893 Prolonged ERK activation events 6.28e-05 6.28e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS REAC:109704 PI3K Cascade 6.48e-05 6.48e-05 1 FGFR2,FGFR3,STK11,PIK3CA,AKT1,PIK3R1,PTPN11,MTOR GO:0071383 cellular response to steroid hormone stimulus 6.61e-05 6.61e-05 1 BRCA1,EP300,ARID1A,FOXA1,RB1,TAF1,CTNNB1,AR,CRIPAK GO:0072395 signal transduction involved in cell cycle checkpoint 6.63e-05 6.63e-05 1 EP300,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0044774 mitotic DNA integrity checkpoint 6.67e-05 6.67e-05 1 EP300,CCND1,CDKN1B,CDKN1A,TP53,ATM,NPM1,CHEK2 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity 6.75e-05 6.75e-05 1 APC,CDKN2A,PTEN,CEBPA GO:1904030 negative regulation of cyclin-dependent protein kinase activity 6.75e-05 6.75e-05 1 APC,CDKN2A,PTEN,CEBPA REAC:5655332 Signaling by FGFR3 in disease 7.05e-05 7.05e-05 1 FGFR3,PIK3CA,KRAS,PIK3R1,NRAS REAC:8853338 Signaling by FGFR3 point mutants in cancer 7.05e-05 7.05e-05 1 FGFR3,PIK3CA,KRAS,PIK3R1,NRAS GO:0044744 protein targeting to nucleus 7.15e-05 7.15e-05 1 CDH1,KEAP1,TLR4,AKT1,PIK3R1,EGFR,CTNNB1,ERBB4,NF1 GO:0006606 protein import into nucleus 7.15e-05 7.15e-05 1 CDH1,KEAP1,TLR4,AKT1,PIK3R1,EGFR,CTNNB1,ERBB4,NF1 GO:1902593 single-organism nuclear import 7.45e-05 7.45e-05 1 CDH1,KEAP1,TLR4,AKT1,PIK3R1,EGFR,CTNNB1,ERBB4,NF1 REAC:167044 Signalling to RAS 7.46e-05 7.46e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS REAC:5218921 VEGFR2 mediated cell proliferation 8.12e-05 8.12e-05 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS GO:0090316 positive regulation of intracellular protein transport 8.67e-05 8.67e-05 1 CDH1,FBXW7,TLR4,TP53,SMAD4,PIK3R1,EGFR,U2AF1,BAP1,ERBB4 GO:0051983 regulation of chromosome segregation 9.63e-05 9.63e-05 1 ATRX,CTCF,APC,RB1,ATM,RAD21,CTNNB1,AXIN2 REAC:187687 Signalling to ERKs 1.00e-04 1.00e-04 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS GO:0018205 peptidyl-lysine modification 1.02e-04 1.02e-04 1 BRCA1,ATRX,EP300,EZH2,BRCA2,SMAD4,KDM6A,CDKN2A,NSD1,CTNNB1,TET2,SIN3A,SETD2 GO:0032875 regulation of DNA endoreduplication 1.02e-04 1.02e-04 1 SMC1A,STAG2,SMC3,FBXW7 GO:0022612 gland morphogenesis 1.04e-04 1.04e-04 1 HGF,FGFR2,FBXW7,SOX9,ELF3 GO:0009755 hormone-mediated signaling pathway 1.09e-04 1.09e-04 1 BRCA1,EP300,ARID1A,FOXA1,RB1,TAF1,CTNNB1,AR,CRIPAK GO:0061180 mammary gland epithelium development 1.15e-04 1.15e-04 1 FGFR2,GATA3,BRCA2,AKT1,ERBB4 GO:0061458 reproductive system development 1.16e-04 1.16e-04 1 FGFR2,GATA3,SOX9,PDGFRA,TBX3,KIT,AR,PTPN11,WT1 GO:0048608 reproductive structure development 1.16e-04 1.16e-04 1 FGFR2,GATA3,SOX9,PDGFRA,TBX3,KIT,AR,PTPN11,WT1 GO:0006338 chromatin remodeling 1.16e-04 1.16e-04 1 ATRX,ARID1A,SOX9,FOXA1,RB1,CDKN2A,PBRM1,NPM1 GO:0019216 regulation of lipid metabolic process 1.17e-04 1.17e-04 1 BRCA1,FGFR3,FBXW7,FLT3,PDGFRA,RB1,AKT1,PIK3R1,KIT,MTOR REAC:1963642 PI3K events in ERBB2 signaling 1.25e-04 1.25e-04 1 PIK3CA,PIK3R1,EGFR GO:0097193 intrinsic apoptotic signaling pathway 1.29e-04 1.29e-04 1 BRCA1,EP300,FBXW7,NFE2L2,STK11,CDKN1A,TP53,AKT1,CHEK2,LRRK2 GO:0001822 kidney development 1.49e-04 1.49e-04 1 FGFR2,GATA3,SOX9,PDGFRA,CTNNB1,WT1,LRRK2,NF1 REAC:5683057 MAPK family signaling cascades 1.52e-04 1.52e-04 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,PTPN11,NF1,NRAS GO:0051170 nuclear import 1.55e-04 1.55e-04 1 CDH1,KEAP1,TLR4,AKT1,PIK3R1,EGFR,CTNNB1,ERBB4,NF1 REAC:1963640 GRB2 events in ERBB2 signaling 1.60e-04 1.60e-04 1 KRAS,EGFR,ERBB4,NRAS GO:0042306 regulation of protein import into nucleus 1.72e-04 1.72e-04 1 CDH1,KEAP1,TLR4,SMAD4,PIK3R1,EGFR,ERBB4,NF1 REAC:375165 NCAM signaling for neurite out-growth 1.76e-04 1.76e-04 1 HGF,FGFR2,FGFR3,PPP2R1A,KRAS,PDGFRA,EGFR,KIT,BRAF,ERBB4,NF1,NRAS REAC:8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1.77e-04 1.77e-04 1 KRAS,ARHGAP35,NF1,NRAS GO:0010506 regulation of autophagy 1.78e-04 1.78e-04 1 HGF,EP300,FBXW7,STK11,PIK3CA,AKT1,ATM,U2AF1,LRRK2,MTOR GO:0009416 response to light stimulus 1.86e-04 1.86e-04 1 EP300,CCND1,STK11,CDKN1A,TP53,AKT1,EGFR,TAF1,ATR,NF1 GO:0061061 muscle structure development 1.92e-04 1.92e-04 1 FGFR2,SOX9,PDGFRA,TBX3,RB1,SMAD4,NOTCH1,KIT,CTNNB1,ERBB4,WT1 GO:0008213 protein alkylation 1.93e-04 1.93e-04 1 BRCA1,ATRX,EZH2,SMAD4,KDM6A,NSD1,CTNNB1,TET2,SETD2 GO:0006479 protein methylation 1.93e-04 1.93e-04 1 BRCA1,ATRX,EZH2,SMAD4,KDM6A,NSD1,CTNNB1,TET2,SETD2 GO:0030522 intracellular receptor signaling pathway 1.97e-04 1.97e-04 1 BRCA1,EP300,ARID1A,FOXA1,RB1,TAF1,CTNNB1,AR,ASXL1,CRIPAK GO:0007548 sex differentiation 2.02e-04 2.02e-04 1 GATA3,SOX9,PDGFRA,TBX3,KIT,AR,PTPN11,WT1 GO:0042023 DNA endoreduplication 2.03e-04 2.03e-04 1 SMC1A,STAG2,SMC3,FBXW7 GO:1904589 regulation of protein import 2.07e-04 2.07e-04 1 CDH1,KEAP1,TLR4,SMAD4,PIK3R1,EGFR,ERBB4,NF1 GO:0035239 tube morphogenesis 2.13e-04 2.13e-04 1 FGFR2,GATA3,SOX9,PDGFRA,NOTCH1,TGFBR2,SOX17,CTNNB1,WT1 GO:0090329 regulation of DNA-dependent DNA replication 2.29e-04 2.29e-04 1 SMC1A,ATRX,STAG2,SMC3,FBXW7,CHEK2 GO:1903829 positive regulation of cellular protein localization 2.30e-04 2.30e-04 1 CDH1,FBXW7,TLR4,TP53,AKT1,PIK3R1,EGFR,U2AF1,BAP1,ERBB4 GO:1901796 regulation of signal transduction by p53 class mediator 2.46e-04 2.46e-04 1 BRCA1,EP300,STK11,TP53,AKT1,TAF1,ATM,ATR,CHEK2 GO:0098813 nuclear chromosome segregation 2.64e-04 2.64e-04 1 SMC1A,ATRX,STAG2,CTCF,SMC3,FBXW7,APC,RB1,ATM,RAD21,CTNNB1,AXIN2 GO:0046824 positive regulation of nucleocytoplasmic transport 2.77e-04 2.77e-04 1 CDH1,TLR4,TP53,SMAD4,PIK3R1,EGFR,ERBB4 GO:0040029 regulation of gene expression, epigenetic 2.81e-04 2.81e-04 1 BRCA1,EP300,CTCF,EZH2,SF3B1,ARID1A,DNMT3A,AJUBA,NCOR1,EGFR,SIN3A,SMAD2 GO:0048729 tissue morphogenesis 2.82e-04 2.82e-04 1 HGF,FGFR2,GATA3,SOX9,TBX3,SMAD4,NOTCH1,ARHGAP35,TGFBR2,SOX17,CTNNB1,WT1 GO:0018105 peptidyl-serine phosphorylation 2.90e-04 2.90e-04 1 STK11,AKT1,TAF1,ATM,BRAF,TGFBR2,NSD1,ATR,CHEK2,LRRK2,MTOR GO:0045860 positive regulation of protein kinase activity 2.93e-04 2.93e-04 1 PIK3CG,FBXW7,CCND1,STK11,FLT3,CDKN1A,TLR4,AKT1,EGFR,KIT,TGFBR2,LRRK2 REAC:2179392 EGFR Transactivation by Gastrin 3.71e-04 3.71e-04 1 KRAS,EGFR,NRAS GO:0051222 positive regulation of protein transport 3.84e-04 3.84e-04 1 CDH1,GATA3,FBXW7,TLR4,TP53,PIK3R1,EGFR,U2AF1,BAP1,ERBB4 REAC:2470946 Cohesin Loading onto Chromatin 3.88e-04 3.88e-04 1 SMC1A,STAG2,SMC3,RAD21 GO:0048545 response to steroid hormone 3.91e-04 3.91e-04 1 BRCA1,EP300,ARID1A,FOXA1,RB1,TAF1,CTNNB1,AR,CRIPAK GO:0018209 peptidyl-serine modification 4.10e-04 4.10e-04 1 STK11,AKT1,TAF1,ATM,BRAF,TGFBR2,NSD1,ATR,CHEK2,LRRK2,MTOR GO:0017038 protein import 4.36e-04 4.36e-04 1 CDH1,KEAP1,TLR4,AKT1,PIK3R1,EGFR,CTNNB1,ERBB4,NF1 REAC:1500620 Meiosis 4.42e-04 4.42e-04 1 BRCA1,SMC1A,STAG2,SMC3,BRCA2,ATM,HIST1H2BD,RAD21,ATR GO:0046620 regulation of organ growth 4.81e-04 4.81e-04 1 FGFR2,NOTCH1,PTEN,ERBB4,WT1 GO:0071901 negative regulation of protein serine/threonine kinase activity 5.47e-04 5.47e-04 1 APC,CDKN2A,PTEN,NF1 GO:1900182 positive regulation of protein localization to nucleus 5.76e-04 5.76e-04 1 CDH1,TLR4,SMAD4,AKT1,PIK3R1,EGFR,ERBB4 REAC:2468052 Establishment of Sister Chromatid Cohesion 6.06e-04 6.06e-04 1 SMC1A,STAG2,SMC3,RAD21 GO:0003281 ventricular septum development 6.07e-04 6.07e-04 1 FGFR2,GATA3,SMAD4,NOTCH1,TGFBR2 GO:0034504 protein localization to nucleus 6.17e-04 6.17e-04 1 CDH1,KEAP1,TLR4,SMAD4,AKT1,PIK3R1,EGFR,CTNNB1,SIN3A,ERBB4,NF1 REAC:1250196 SHC1 events in ERBB2 signaling 6.31e-04 6.31e-04 1 KRAS,EGFR,ERBB4,NRAS GO:0051568 histone H3-K4 methylation 6.45e-04 6.45e-04 1 BRCA1,SMAD4,KDM6A,CTNNB1,TET2 GO:2000679 positive regulation of transcription regulatory region DNA binding 6.63e-04 6.63e-04 1 GATA3,RB1,CTNNB1 GO:0007265 Ras protein signal transduction 6.73e-04 6.73e-04 1 KRAS,RB1,TP53,CDKN2A,NF1 GO:0003007 heart morphogenesis 6.79e-04 6.79e-04 1 FGFR2,GATA3,SOX9,SMAD4,NOTCH1,TGFBR2,SOX17,CTNNB1 REAC:2559586 DNA Damage/Telomere Stress Induced Senescence 6.89e-04 6.89e-04 1 CDKN1B,CDKN1A,RB1,TP53,ATM,HIST1H2BD,HIST1H1C GO:0051147 regulation of muscle cell differentiation 7.07e-04 7.07e-04 1 FGFR2,SOX9,TBX3,SMAD4,NOTCH1,KIT,CTNNB1 REAC:2559583 Cellular Senescence 7.10e-04 7.10e-04 1 MAP2K4,EZH2,CDKN1B,CDKN2C,CDKN1A,RB1,TP53,CDKN2A,ATM,HIST1H2BD,HIST1H1C REAC:5655302 Signaling by FGFR1 in disease 7.29e-04 7.29e-04 1 PIK3CA,KRAS,PIK3R1,NRAS GO:0043551 regulation of phosphatidylinositol 3-kinase activity 7.54e-04 7.54e-04 1 FGFR3,FLT3,PDGFRA,PIK3R1,KIT GO:0048485 sympathetic nervous system development 8.16e-04 8.16e-04 1 GATA3,CTNNB1,NF1 GO:0071478 cellular response to radiation 8.34e-04 8.34e-04 1 EP300,GATA3,STK11,CDKN1A,TP53,TAF1,ATM,ATR GO:0031929 TOR signaling 8.61e-04 8.61e-04 1 GATA3,STK11,PIK3CA,AKT1,ATM,MTOR GO:0032388 positive regulation of intracellular transport 8.87e-04 8.87e-04 1 CDH1,FBXW7,TLR4,TP53,PIK3R1,EGFR,U2AF1,BAP1,ERBB4 GO:0061138 morphogenesis of a branching epithelium 8.89e-04 8.89e-04 1 HGF,FGFR2,SOX9,TGFBR2,CTNNB1,WT1 GO:0071681 cellular response to indole-3-methanol 8.95e-04 8.95e-04 1 BRCA1,CDH1,CTNNB1 GO:0071680 response to indole-3-methanol 8.95e-04 8.95e-04 1 BRCA1,CDH1,CTNNB1 REAC:1226099 Signaling by FGFR in disease 9.03e-04 9.03e-04 1 FGFR2,FGFR3,PIK3CA,KRAS,PIK3R1,NRAS GO:0048598 embryonic morphogenesis 9.07e-04 9.07e-04 1 FGFR2,GATA3,SOX9,FOXA2,PDGFRA,TBX3,NOTCH1,TGFBR2,SOX17,CTNNB1 GO:0010639 negative regulation of organelle organization 9.15e-04 9.15e-04 1 BRCA1,HGF,ATRX,APC,SMAD4,AKT1,ATM,SIN3A,NPM1,LRRK2 GO:0022407 regulation of cell-cell adhesion 9.35e-04 9.35e-04 1 CDH1,GATA3,PIK3CA,FOXA2,FOXA1,AKT1,PIK3R1,CDKN2A,TGFBR2,PTPN11,MTOR GO:1903201 regulation of oxidative stress-induced cell death 9.57e-04 9.57e-04 1 HGF,FBXW7,NFE2L2,AKT1,LRRK2 REAC:389357 CD28 dependent PI3K/Akt signaling 9.92e-04 9.92e-04 1 PIK3CA,AKT1,PIK3R1,MTOR GO:0016242 negative regulation of macroautophagy 1.02e-03 1.02e-03 1 PIK3CA,AKT1,LRRK2,MTOR REAC:6804760 Regulation of TP53 Activity through Methylation 1.04e-03 1.04e-03 1 EP300,TP53,ATM,CHEK2 GO:0042176 regulation of protein catabolic process 1.05e-03 1.05e-03 1 KEAP1,FBXW7,CDKN1B,NFE2L2,APC,EGFR,PTEN,CHEK2,LRRK2,CEBPA GO:2001233 regulation of apoptotic signaling pathway 1.12e-03 1.12e-03 1 BRCA1,HGF,FBXW7,NFE2L2,TP53,AKT1,AR,PTEN,LRRK2 REAC:1502540 Signaling by Activin 1.14e-03 1.14e-03 1 ACVR2A,ACVR1B,SMAD4,SMAD2 GO:0060562 epithelial tube morphogenesis 1.17e-03 1.17e-03 1 FGFR2,GATA3,SOX9,NOTCH1,TGFBR2,SOX17,CTNNB1,WT1 GO:0010212 response to ionizing radiation 1.19e-03 1.19e-03 1 BRCA1,GATA3,STK11,CDKN1A,TP53,ATM,ATR REAC:5655253 Signaling by FGFR2 in disease 1.21e-03 1.21e-03 1 PIK3CA,KRAS,PIK3R1,NRAS GO:0043414 macromolecule methylation 1.23e-03 1.23e-03 1 BRCA1,ATRX,EZH2,DNMT3A,SMAD4,KDM6A,NSD1,CTNNB1,TET2,SETD2 GO:0034644 cellular response to UV 1.24e-03 1.24e-03 1 EP300,STK11,CDKN1A,TP53,TAF1,ATR GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle 1.28e-03 1.28e-03 1 AKT1,EGFR,PTEN GO:0048705 skeletal system morphogenesis 1.31e-03 1.31e-03 1 FGFR2,FGFR3,SOX9,PDGFRA,TGFBR2,CTNNB1 REAC:2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1.31e-03 1.31e-03 1 CDKN1A,RB1,TP53,HIST1H1C REAC:5693532 DNA Double-Strand Break Repair 1.40e-03 1.40e-03 1 BRCA1,POLQ,BRCA2,TP53,ATM,HIST1H2BD,BAP1,ATR,CHEK2 GO:0060421 positive regulation of heart growth 1.42e-03 1.42e-03 1 FGFR2,NOTCH1,ERBB4,WT1 GO:0046622 positive regulation of organ growth 1.42e-03 1.42e-03 1 FGFR2,NOTCH1,ERBB4,WT1 GO:0048562 embryonic organ morphogenesis 1.49e-03 1.49e-03 1 FGFR2,SOX9,PDGFRA,NOTCH1,TGFBR2,SOX17,CTNNB1 GO:0022409 positive regulation of cell-cell adhesion 1.59e-03 1.59e-03 1 GATA3,PIK3CA,FOXA2,FOXA1,AKT1,PIK3R1,TGFBR2,PTPN11,MTOR GO:0031056 regulation of histone modification 1.59e-03 1.59e-03 1 BRCA1,ATRX,TP53,SMAD4,NSD1,CTNNB1,SIN3A REAC:6804756 Regulation of TP53 Activity through Phosphorylation 1.61e-03 1.61e-03 1 BRCA1,STK11,TP53,TAF1,ATM,ATR,CHEK2 GO:0048568 embryonic organ development 1.68e-03 1.68e-03 1 FGFR2,SOX9,PDGFRA,NOTCH1,KIT,TGFBR2,SOX17,CTNNB1 GO:0048709 oligodendrocyte differentiation 1.72e-03 1.72e-03 1 NOTCH1,PTEN,NF1 GO:2000027 regulation of organ morphogenesis 1.77e-03 1.77e-03 1 HGF,FGFR2,GATA3,FBXW7,SOX9,TGFBR2,CTNNB1,WT1 REAC:68884 Mitotic Telophase/Cytokinesis 1.80e-03 1.80e-03 1 SMC1A,STAG2,SMC3,RAD21 REAC:69563 p53-Dependent G1 DNA Damage Response 1.80e-03 1.80e-03 1 CDKN1B,CDKN1A,TP53,CDKN2A,ATM,CHEK2 REAC:69580 p53-Dependent G1/S DNA damage checkpoint 1.80e-03 1.80e-03 1 CDKN1B,CDKN1A,TP53,CDKN2A,ATM,CHEK2 GO:0042307 positive regulation of protein import into nucleus 1.86e-03 1.86e-03 1 CDH1,TLR4,SMAD4,PIK3R1,EGFR,ERBB4 GO:0002521 leukocyte differentiation 1.87e-03 1.87e-03 1 GATA3,FLT3,TLR4,CDKN2A,ATM,KIT,RUNX1,TGFBR2,MTOR,CEBPA GO:0010507 negative regulation of autophagy 1.89e-03 1.89e-03 1 HGF,PIK3CA,AKT1,LRRK2,MTOR GO:1900407 regulation of cellular response to oxidative stress 1.89e-03 1.89e-03 1 HGF,FBXW7,NFE2L2,AKT1,LRRK2 GO:0050678 regulation of epithelial cell proliferation 2.14e-03 2.14e-03 1 FGFR2,GATA3,FBXW7,SOX9,BRCA2,AKT1,EGFR,EGR3,NF1 REAC:69615 G1/S DNA Damage Checkpoints 2.14e-03 2.14e-03 1 CDKN1B,CDKN1A,TP53,CDKN2A,ATM,CHEK2 GO:1904894 positive regulation of STAT cascade 2.17e-03 2.17e-03 1 FLT3,NOTCH1,KIT,ERBB4 GO:0046427 positive regulation of JAK-STAT cascade 2.17e-03 2.17e-03 1 FLT3,NOTCH1,KIT,ERBB4 GO:1904591 positive regulation of protein import 2.18e-03 2.18e-03 1 CDH1,TLR4,SMAD4,PIK3R1,EGFR,ERBB4 GO:0009880 embryonic pattern specification 2.23e-03 2.23e-03 1 FGFR2,TBX3,SMAD2,ERBB4,WT1 GO:0048483 autonomic nervous system development 2.24e-03 2.24e-03 1 GATA3,CTNNB1,NF1 REAC:1221632 Meiotic synapsis 2.24e-03 2.24e-03 1 BRCA1,SMC1A,STAG2,SMC3,HIST1H2BD,RAD21,ATR GO:0006359 regulation of transcription from RNA polymerase III promoter 2.26e-03 2.26e-03 1 BRCA1,AR,MTOR,CEBPA GO:0006261 DNA-dependent DNA replication 2.28e-03 2.28e-03 1 POLQ,SMC1A,ATRX,STAG2,SMC3,FBXW7,BRCA2,CHEK2 GO:0071902 positive regulation of protein serine/threonine kinase activity 2.29e-03 2.29e-03 1 PIK3CG,CCND1,STK11,FLT3,TLR4,AKT1,EGFR,KIT,LRRK2 GO:0001503 ossification 2.30e-03 2.30e-03 1 HGF,FGFR2,FGFR3,ACVR2A,SOX9,EGFR,NOTCH1,RUNX1,AXIN2,NF1 GO:0038095 Fc-epsilon receptor signaling pathway 2.31e-03 2.31e-03 1 MAP2K4,MAP3K1,PIK3CA,KRAS,PIK3R1,NRAS GO:0001667 ameboidal-type cell migration 2.34e-03 2.34e-03 1 GATA3,PIK3CA,SOX9,ACVR1B,AKT1,NOTCH1,KIT,ERBB4,EGR3,NF1 GO:0006333 chromatin assembly or disassembly 2.36e-03 2.36e-03 1 ATRX,CTCF,ARID1A,SOX9,TP53,CDKN2A,NPM1 GO:0001656 metanephros development 2.44e-03 2.44e-03 1 GATA3,SOX9,PDGFRA,WT1,NF1 GO:0033002 muscle cell proliferation 2.53e-03 2.53e-03 1 FGFR2,CDKN1B,AKT1,NOTCH1,CTNNB1,ERBB4 REAC:3769402 Deactivation of the beta-catenin transactivating complex 2.53e-03 2.53e-03 1 SOX9,APC,AKT1,SOX17,CTNNB1 GO:1902882 regulation of response to oxidative stress 2.57e-03 2.57e-03 1 HGF,FBXW7,NFE2L2,AKT1,LRRK2 GO:0002009 morphogenesis of an epithelium 2.62e-03 2.62e-03 1 HGF,FGFR2,GATA3,SOX9,NOTCH1,ARHGAP35,TGFBR2,SOX17,CTNNB1,WT1 GO:0032259 methylation 2.64e-03 2.64e-03 1 BRCA1,ATRX,EZH2,DNMT3A,SMAD4,KDM6A,NSD1,CTNNB1,TET2,SETD2 GO:0036473 cell death in response to oxidative stress 2.84e-03 2.84e-03 1 HGF,FBXW7,NFE2L2,AKT1,LRRK2 GO:0070141 response to UV-A 3.01e-03 3.01e-03 1 CCND1,AKT1,EGFR GO:0007264 small GTPase mediated signal transduction 3.13e-03 3.13e-03 1 KRAS,RB1,TP53,CDKN2A,ARHGAP35,NF1,NRAS GO:1901800 positive regulation of proteasomal protein catabolic process 3.15e-03 3.15e-03 1 KEAP1,FBXW7,NFE2L2,TAF1,LRRK2,CEBPA GO:0051493 regulation of cytoskeleton organization 3.15e-03 3.15e-03 1 BRCA1,EPHA3,PDGFRA,APC,SMAD4,ARHGAP35,CTNNB1,CRIPAK,NPM1,MTOR REAC:2559585 Oncogene Induced Senescence 3.17e-03 3.17e-03 1 RB1,TP53,CDKN2A GO:0018107 peptidyl-threonine phosphorylation 3.20e-03 3.20e-03 1 STK11,ACVR1B,AKT1,TAF1,TGFBR2,CHEK2,LRRK2 GO:0090150 establishment of protein localization to membrane 3.28e-03 3.28e-03 1 CDH1,RPL22,TP53,AKT1,PIK3R1,EGFR,BRAF,AR GO:0071824 protein-DNA complex subunit organization 3.36e-03 3.36e-03 1 ATRX,CTCF,ERCC2,ARID1A,SOX9,RB1,TAF1,HIST1H2BD,NPM1,SETD2 GO:0043523 regulation of neuron apoptotic process 3.37e-03 3.37e-03 1 FBXW7,TP53,CTNNB1,NF1 GO:0010518 positive regulation of phospholipase activity 3.46e-03 3.46e-03 1 FGFR2,FGFR3,PDGFRA,EGFR,KIT GO:0045732 positive regulation of protein catabolic process 3.52e-03 3.52e-03 1 KEAP1,FBXW7,CDKN1B,NFE2L2,APC,PTEN,LRRK2,CEBPA GO:0072089 stem cell proliferation 3.55e-03 3.55e-03 1 FGFR2,MECOM,RUNX1,CTNNB1,LRRK2,NF1 GO:0035051 cardiocyte differentiation 3.61e-03 3.61e-03 1 PDGFRA,SMAD4,EGFR,NOTCH1,SOX17,WT1 GO:0048863 stem cell differentiation 3.61e-03 3.61e-03 1 FGFR2,SOX9,PDGFRA,NOTCH1,KIT,ERBB4 GO:0042990 regulation of transcription factor import into nucleus 3.92e-03 3.92e-03 1 CDH1,KEAP1,PIK3R1,NF1 GO:0001666 response to hypoxia 4.03e-03 4.03e-03 1 EP300,AJUBA,VHL,TP53,SMAD4,NOTCH1,NF1,MTOR GO:0046661 male sex differentiation 4.11e-03 4.11e-03 1 GATA3,SOX9,TBX3,KIT,WT1 GO:0042991 transcription factor import into nucleus 4.15e-03 4.15e-03 1 CDH1,KEAP1,PIK3R1,NF1 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 4.16e-03 4.16e-03 1 HGF,FLT3,SOX9,PDGFRA,KIT GO:0018210 peptidyl-threonine modification 4.20e-03 4.20e-03 1 STK11,ACVR1B,AKT1,TAF1,TGFBR2,CHEK2,LRRK2 GO:0007389 pattern specification process 4.23e-03 4.23e-03 1 FGFR2,FOXA2,TBX3,NOTCH1,TGFBR2,SOX17,SMAD2,ERBB4,WT1 GO:0048511 rhythmic process 4.41e-03 4.41e-03 1 EP300,EZH2,PDGFRA,NCOR1,TP53,KIT,SIN3A,PTEN,EGR3 GO:0010810 regulation of cell-substrate adhesion 4.41e-03 4.41e-03 1 CDKN2A,NOTCH1,PTEN,NF1 GO:0031060 regulation of histone methylation 4.53e-03 4.53e-03 1 BRCA1,ATRX,SMAD4,NSD1,CTNNB1 GO:0036293 response to decreased oxygen levels 4.54e-03 4.54e-03 1 EP300,AJUBA,VHL,TP53,SMAD4,NOTCH1,NF1,MTOR GO:0003151 outflow tract morphogenesis 4.64e-03 4.64e-03 1 FGFR2,SMAD4,TGFBR2,SOX17,CTNNB1 GO:0001501 skeletal system development 4.68e-03 4.68e-03 1 FGFR2,FGFR3,SOX9,PDGFRA,TBX3,KIT,RUNX1,TGFBR2,CTNNB1 GO:0045662 negative regulation of myoblast differentiation 4.71e-03 4.71e-03 1 SOX9,TBX3,NOTCH1 GO:0044839 cell cycle G2/M phase transition 4.72e-03 4.72e-03 1 PPP2R1A,CCND1,CDKN1A,AJUBA,TP53,CDKN2A,ATM,NPM1,CHEK2 GO:0051402 neuron apoptotic process 4.88e-03 4.88e-03 1 FBXW7,TP53,CTNNB1,NF1 GO:0048145 regulation of fibroblast proliferation 4.92e-03 4.92e-03 1 CDKN1A,PDGFRA,TP53,CTNNB1,NF1 GO:0051054 positive regulation of DNA metabolic process 4.95e-03 4.95e-03 1 BRCA1,HGF,ATRX,PDGFRA,AKT1,EGFR,ATM,ATR GO:0061564 axon development 5.12e-03 5.12e-03 1 EPHA3,PIK3CA,KRAS,PIK3R1,ARHGAP35,PTEN,NRAS GO:0060688 regulation of morphogenesis of a branching structure 5.17e-03 5.17e-03 1 HGF,FGFR2,SOX9,LRRK2 GO:0070482 response to oxygen levels 5.29e-03 5.29e-03 1 EP300,AJUBA,VHL,TP53,SMAD4,NOTCH1,NF1,MTOR GO:0007610 behavior 5.37e-03 5.37e-03 1 TP53,EGFR,PTEN,NF1 GO:0048144 fibroblast proliferation 5.51e-03 5.51e-03 1 CDKN1A,PDGFRA,TP53,CTNNB1,NF1 GO:0050852 T cell receptor signaling pathway 5.77e-03 5.77e-03 1 GATA3,PIK3CA,PIK3R1,PTEN REAC:6791312 TP53 Regulates Transcription of Cell Cycle Genes 5.84e-03 5.84e-03 1 EP300,CDKN1B,CDKN1A,TP53,NPM1 REAC:389356 CD28 co-stimulation 5.91e-03 5.91e-03 1 PIK3CA,AKT1,PIK3R1,MTOR GO:1903725 regulation of phospholipid metabolic process 6.03e-03 6.03e-03 1 FGFR3,FLT3,PDGFRA,PIK3R1,KIT REAC:1660499 Synthesis of PIPs at the plasma membrane 6.05e-03 6.05e-03 1 PIK3CA,PIK3R1,PTEN GO:0060420 regulation of heart growth 6.19e-03 6.19e-03 1 FGFR2,NOTCH1,ERBB4,WT1 GO:0001889 liver development 6.39e-03 6.39e-03 1 FBXW7,ARID5B,NF1,CEBPA GO:0034502 protein localization to chromosome 6.56e-03 6.56e-03 1 ATRX,CTCF,BRCA2,RB1,RAD21,ATR REAC:3315487 SMAD2/3 MH2 Domain Mutants in Cancer 6.64e-03 6.64e-03 1 SMAD4,TGFBR2,SMAD2 REAC:3304349 Loss of Function of SMAD2/3 in Cancer 6.64e-03 6.64e-03 1 SMAD4,TGFBR2,SMAD2 REAC:5674400 Constitutive Signaling by AKT1 E17K in Cancer 6.68e-03 6.68e-03 1 CDKN1B,CDKN1A,AKT1,MTOR GO:0090183 regulation of kidney development 6.77e-03 6.77e-03 1 GATA3,SOX9,CTNNB1,WT1 REAC:5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 6.78e-03 6.78e-03 1 BRCA1,TP53,ATM,HIST1H2BD,BAP1,CHEK2 GO:0003279 cardiac septum development 6.80e-03 6.80e-03 1 FGFR2,GATA3,SMAD4,NOTCH1,TGFBR2 GO:0071479 cellular response to ionizing radiation 6.87e-03 6.87e-03 1 GATA3,CDKN1A,TP53,ATM,ATR GO:0034599 cellular response to oxidative stress 6.90e-03 6.90e-03 1 HGF,FBXW7,NFE2L2,PDGFRA,TP53,AKT1,LRRK2 REAC:69620 Cell Cycle Checkpoints 7.03e-03 7.03e-03 1 BRCA1,CDKN1B,CDKN1A,TP53,CDKN2A,ATM,HIST1H2BD,ATR,CHEK2 GO:0071417 cellular response to organonitrogen compound 7.09e-03 7.09e-03 1 BRCA1,CDH1,PIK3CA,SOX9,AKT1,PIK3R1,TAF1,CTNNB1,PTPN11,WT1,LRRK2 GO:0050673 epithelial cell proliferation 7.22e-03 7.22e-03 1 FGFR2,GATA3,FBXW7,SOX9,BRCA2,AKT1,EGFR,EGR3,NF1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 7.24e-03 7.24e-03 1 EP300,FOXA2,SMAD4,NOTCH1 REAC:5693606 DNA Double Strand Break Response 7.31e-03 7.31e-03 1 BRCA1,TP53,ATM,HIST1H2BD,BAP1,CHEK2 GO:0061008 hepaticobiliary system development 7.32e-03 7.32e-03 1 FBXW7,ARID5B,NF1,CEBPA GO:0007405 neuroblast proliferation 7.34e-03 7.34e-03 1 FGFR2,CTNNB1,LRRK2,NF1 GO:0045945 positive regulation of transcription from RNA polymerase III promoter 7.46e-03 7.46e-03 1 AR,MTOR,CEBPA GO:0051101 regulation of DNA binding 7.83e-03 7.83e-03 1 GATA3,RB1,TAF1,NSD1,CTNNB1,SIN3A GO:0048514 blood vessel morphogenesis 7.86e-03 7.86e-03 1 BRCA1,FGFR2,PDGFRA,NOTCH1,RUNX1,TGFBR2,SOX17,CTNNB1,WT1,NF1 GO:0043388 positive regulation of DNA binding 7.87e-03 7.87e-03 1 GATA3,RB1,CTNNB1 GO:0060070 canonical Wnt signaling pathway 7.89e-03 7.89e-03 1 FGFR2,GATA3,SOX9,APC,SOX17,CTNNB1,AXIN2,PTEN,TBL1XR1,LRRK2 GO:0043542 endothelial cell migration 7.91e-03 7.91e-03 1 GATA3,PIK3CA,NOTCH1,NF1 GO:0050767 regulation of neurogenesis 8.01e-03 8.01e-03 1 EPHA3,SOX9,AKT1,NOTCH1,ARHGAP35,CTNNB1,PTEN,NF1 GO:0060412 ventricular septum morphogenesis 8.15e-03 8.15e-03 1 FGFR2,SMAD4,NOTCH1,TGFBR2 GO:0010517 regulation of phospholipase activity 8.18e-03 8.18e-03 1 FGFR2,FGFR3,PDGFRA,EGFR,KIT REAC:5673000 RAF activation 8.23e-03 8.23e-03 1 PPP2R1A,KRAS,BRAF,NRAS REAC:388841 Costimulation by the CD28 family 8.25e-03 8.25e-03 1 PPP2R1A,PIK3CA,AKT1,PIK3R1,PTPN11,MTOR REAC:6796648 TP53 Regulates Transcription of DNA Repair Genes 8.57e-03 8.57e-03 1 BRCA1,ERCC2,TP53,ATM,CDK12,ATR GO:0097485 neuron projection guidance 8.74e-03 8.74e-03 1 PIK3CA,KRAS,PIK3R1,ARHGAP35,NRAS GO:0007411 axon guidance 8.74e-03 8.74e-03 1 PIK3CA,KRAS,PIK3R1,ARHGAP35,NRAS GO:1900408 negative regulation of cellular response to oxidative stress 8.82e-03 8.82e-03 1 HGF,NFE2L2,AKT1,LRRK2 GO:1902883 negative regulation of response to oxidative stress 8.82e-03 8.82e-03 1 HGF,NFE2L2,AKT1,LRRK2 GO:1903202 negative regulation of oxidative stress-induced cell death 8.82e-03 8.82e-03 1 HGF,NFE2L2,AKT1,LRRK2 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 8.85e-03 8.85e-03 1 FGFR3,FLT3,PDGFRA,KIT GO:0030099 myeloid cell differentiation 9.57e-03 9.57e-03 1 ACVR2A,ACVR1B,TLR4,KIT,RUNX1,TGFBR2,TET2,MTOR,CEBPA GO:1902275 regulation of chromatin organization 9.61e-03 9.61e-03 1 BRCA1,ATRX,TP53,SMAD4,NSD1,CTNNB1,SIN3A GO:0032927 positive regulation of activin receptor signaling pathway 9.97e-03 9.97e-03 1 ACVR2A,ACVR1B,SMAD2 GO:0003208 cardiac ventricle morphogenesis 1.02e-02 1.02e-02 1 FGFR2,GATA3,SMAD4,NOTCH1,TGFBR2 GO:1903706 regulation of hemopoiesis 1.04e-02 1.04e-02 1 GATA3,ACVR2A,ACVR1B,TLR4,CDKN2A,NOTCH1,RUNX1,TGFBR2,MTOR REAC:392451 G beta:gamma signalling through PI3Kgamma 1.05e-02 1.05e-02 1 PIK3CG,PIK3CA,AKT1,PIK3R1 REAC:3304351 Signaling by TGF-beta Receptor Complex in Cancer 1.06e-02 1.06e-02 1 SMAD4,TGFBR2,SMAD2 GO:0007409 axonogenesis 1.07e-02 1.07e-02 1 PIK3CA,KRAS,PIK3R1,ARHGAP35,PTEN,NRAS GO:0060193 positive regulation of lipase activity 1.09e-02 1.09e-02 1 FGFR2,FGFR3,PDGFRA,EGFR,KIT REAC:109581 Apoptosis 1.09e-02 1.09e-02 1 CDH1,APC,TLR4,TP53,AKT1,CTNNB1,HIST1H1C REAC:1181150 Signaling by NODAL 1.10e-02 1.10e-02 1 ACVR2A,ACVR1B,SMAD4,SMAD2 GO:0070374 positive regulation of ERK1 and ERK2 cascade 1.10e-02 1.10e-02 1 FGFR2,FGFR3,FBXW7,PDGFRA,EGFR,BRAF,ERBB4 GO:0048589 developmental growth 1.10e-02 1.10e-02 1 FGFR2,FGFR3,USP9X,SOX9,NOTCH1,PTEN,ERBB4,WT1 GO:0010812 negative regulation of cell-substrate adhesion 1.11e-02 1.11e-02 1 CDKN2A,NOTCH1,PTEN GO:1902692 regulation of neuroblast proliferation 1.11e-02 1.11e-02 1 CTNNB1,LRRK2,NF1 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 1.11e-02 1.11e-02 1 NFE2L2,TP53,NOTCH1 GO:0048738 cardiac muscle tissue development 1.15e-02 1.15e-02 1 FGFR2,PDGFRA,SMAD4,NOTCH1,ERBB4,WT1 GO:0003006 developmental process involved in reproduction 1.16e-02 1.16e-02 1 FGFR2,GATA3,SOX9,PDGFRA,TBX3,KIT,AR,WT1 GO:0038093 Fc receptor signaling pathway 1.21e-02 1.21e-02 1 MAP2K4,MAP3K1,PIK3CA,KRAS,PIK3R1,NRAS REAC:5357801 Programmed Cell Death 1.22e-02 1.22e-02 1 CDH1,APC,TLR4,TP53,AKT1,CTNNB1,HIST1H1C REAC:69242 S Phase 1.26e-02 1.26e-02 1 SMC1A,STAG2,SMC3,CCND1,CDKN1B,CDKN1A,RB1,RAD21 GO:0060537 muscle tissue development 1.28e-02 1.28e-02 1 FGFR2,PDGFRA,SMAD4,NOTCH1,ERBB4,WT1,NF1 GO:0043409 negative regulation of MAPK cascade 1.31e-02 1.31e-02 1 MECOM,PPP2R1A,TLR4,NCOR1,SMAD4,PTEN,NF1 REAC:2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 1.32e-02 1.32e-02 1 USP9X,NCOR1,SMAD4,SMAD2 REAC:397795 G-protein beta:gamma signalling 1.33e-02 1.33e-02 1 PIK3CG,PIK3CA,AKT1,PIK3R1 GO:0031497 chromatin assembly 1.33e-02 1.33e-02 1 ATRX,CTCF,SOX9,TP53,CDKN2A,NPM1 GO:0042110 T cell activation 1.35e-02 1.35e-02 1 PIK3CG,GATA3,PIK3CA,AKT1,PIK3R1,CDKN2A,KIT,TGFBR2,PTPN11,MTOR GO:0048704 embryonic skeletal system morphogenesis 1.36e-02 1.36e-02 1 FGFR2,PDGFRA,TGFBR2,CTNNB1 GO:0001568 blood vessel development 1.41e-02 1.41e-02 1 BRCA1,FGFR2,PDGFRA,NOTCH1,RUNX1,TGFBR2,SOX17,CTNNB1,WT1,NF1 GO:0043405 regulation of MAP kinase activity 1.44e-02 1.44e-02 1 PPP2R1A,PIK3CG,EZH2,FLT3,TLR4,EGFR,KIT,CDK12,LRRK2,NF1 GO:0090218 positive regulation of lipid kinase activity 1.45e-02 1.45e-02 1 FGFR3,FLT3,PDGFRA,KIT GO:0045445 myoblast differentiation 1.48e-02 1.48e-02 1 SOX9,TBX3,RB1,NOTCH1 GO:0043627 response to estrogen 1.48e-02 1.48e-02 1 BRCA1,EP300,GATA3,CRIPAK REAC:2122947 NOTCH1 Intracellular Domain Regulates Transcription 1.51e-02 1.51e-02 1 EP300,FBXW7,NCOR1,NOTCH1,TBL1XR1 GO:0001525 angiogenesis 1.52e-02 1.52e-02 1 BRCA1,FGFR2,PDGFRA,NOTCH1,RUNX1,TGFBR2,SOX17,CTNNB1,EGR3,NF1 GO:1901214 regulation of neuron death 1.53e-02 1.53e-02 1 FBXW7,TP53,CTNNB1,NF1 GO:0007611 learning or memory 1.58e-02 1.58e-02 1 EGFR,PTEN,NF1 GO:0048754 branching morphogenesis of an epithelial tube 1.60e-02 1.60e-02 1 FGFR2,SOX9,TGFBR2,CTNNB1,WT1 GO:0045834 positive regulation of lipid metabolic process 1.66e-02 1.66e-02 1 FGFR3,FLT3,PDGFRA,AKT1,KIT,MTOR GO:0071482 cellular response to light stimulus 1.66e-02 1.66e-02 1 EP300,STK11,CDKN1A,TP53,TAF1,ATR GO:0050730 regulation of peptidyl-tyrosine phosphorylation 1.69e-02 1.69e-02 1 FBXW7,FLT3,TP53,EGFR REAC:111465 Apoptotic cleavage of cellular proteins 1.69e-02 1.69e-02 1 CDH1,APC,CTNNB1 GO:0030850 prostate gland development 1.71e-02 1.71e-02 1 FGFR2,SOX9,AR GO:0021953 central nervous system neuron differentiation 1.76e-02 1.76e-02 1 FGFR2,ARHGAP35,CTNNB1,PTEN,ERBB4 REAC:114604 GPVI-mediated activation cascade 1.77e-02 1.77e-02 1 PIK3CG,PIK3CA,AKT1,PIK3R1 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 1.78e-02 1.78e-02 1 KEAP1,FBXW7,NFE2L2,APC,TP53,CTNNB1,CEBPA GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 1.78e-02 1.78e-02 1 BRCA1,EP300,FOXA1,TAF1,CRIPAK GO:0060419 heart growth 1.79e-02 1.79e-02 1 FGFR2,NOTCH1,ERBB4,WT1 GO:2000379 positive regulation of reactive oxygen species metabolic process 1.80e-02 1.80e-02 1 CDKN1A,TP53,AKT1,EGFR,TGFBR2 GO:0070601 centromeric sister chromatid cohesion 1.83e-02 1.83e-02 1 CTCF,CTNNB1,AXIN2 GO:0003170 heart valve development 1.85e-02 1.85e-02 1 GATA3,SOX9,NOTCH1,TGFBR2 GO:0003179 heart valve morphogenesis 1.85e-02 1.85e-02 1 GATA3,SOX9,NOTCH1,TGFBR2 GO:0010165 response to X-ray 1.88e-02 1.88e-02 1 GATA3,TP53,ATM GO:1901342 regulation of vasculature development 1.91e-02 1.91e-02 1 BRCA1,NOTCH1,KIT,RUNX1,CTNNB1,WT1,NF1 REAC:3108214 SUMOylation of DNA damage response and repair proteins 1.97e-02 1.97e-02 1 BRCA1,SMC1A,STAG2,SMC3,CDKN2A,RAD21 GO:0072073 kidney epithelium development 2.05e-02 2.05e-02 1 FGFR2,GATA3,SOX9,CTNNB1,WT1 REAC:453279 Mitotic G1-G1/S phases 2.06e-02 2.06e-02 1 PPP2R1A,CCND1,CDKN1B,CDKN2C,CDKN1A,RB1,AKT1,CDKN2A GO:0061213 positive regulation of mesonephros development 2.12e-02 2.12e-02 1 GATA3,SOX9,WT1 GO:0050863 regulation of T cell activation 2.14e-02 2.14e-02 1 GATA3,PIK3CA,PIK3R1,CDKN2A GO:0009895 negative regulation of catabolic process 2.17e-02 2.17e-02 1 HGF,PIK3CA,AKT1,EGFR,TAF1,LRRK2,MTOR GO:0010631 epithelial cell migration 2.19e-02 2.19e-02 1 GATA3,PIK3CA,SOX9,AKT1,NOTCH1,KIT,NF1 GO:0019827 stem cell population maintenance 2.20e-02 2.20e-02 1 SOX9,SMAD4,NOTCH1,KIT,CTNNB1,SMAD2 REAC:5654732 Negative regulation of FGFR3 signaling 2.22e-02 2.22e-02 1 FGFR3,PPP2R1A,BRAF,PTPN11 GO:0072080 nephron tubule development 2.24e-02 2.24e-02 1 GATA3,SOX9,CTNNB1,WT1 GO:2000146 negative regulation of cell motility 2.26e-02 2.26e-02 1 GATA3,NOTCH1,PTEN,NF1 REAC:1483255 PI Metabolism 2.27e-02 2.27e-02 1 PIK3CA,PIK3R1,PTEN GO:0048667 cell morphogenesis involved in neuron differentiation 2.28e-02 2.28e-02 1 FGFR2,PIK3CA,USP9X,KRAS,PIK3R1,ARHGAP35,PTEN,LRRK2,NRAS REAC:212165 Epigenetic regulation of gene expression 2.31e-02 2.31e-02 1 EP300,ERCC2,EZH2,SF3B1,DNMT3A,HIST1H2BD,TET2,SIN3A GO:0070997 neuron death 2.32e-02 2.32e-02 1 FBXW7,TP53,CTNNB1,NF1 GO:2000377 regulation of reactive oxygen species metabolic process 2.32e-02 2.32e-02 1 BRCA1,CDKN1A,TP53,AKT1,EGFR,TGFBR2 GO:0001952 regulation of cell-matrix adhesion 2.32e-02 2.32e-02 1 CDKN2A,PTEN,NF1 GO:0010821 regulation of mitochondrion organization 2.35e-02 2.35e-02 1 HGF,FBXW7,TP53,AKT1,U2AF1,BAP1,LRRK2 GO:0060045 positive regulation of cardiac muscle cell proliferation 2.35e-02 2.35e-02 1 FGFR2,NOTCH1,ERBB4 GO:0090132 epithelium migration 2.35e-02 2.35e-02 1 GATA3,PIK3CA,SOX9,AKT1,NOTCH1,KIT,NF1 GO:0098727 maintenance of cell number 2.37e-02 2.37e-02 1 SOX9,SMAD4,NOTCH1,KIT,CTNNB1,SMAD2 REAC:198323 AKT phosphorylates targets in the cytosol 2.40e-02 2.40e-02 1 CDKN1B,CDKN1A,AKT1 GO:0050680 negative regulation of epithelial cell proliferation 2.42e-02 2.42e-02 1 GATA3,FBXW7,SOX9,BRCA2,NF1 GO:1905475 regulation of protein localization to membrane 2.42e-02 2.42e-02 1 TP53,AKT1,PIK3R1,EGFR,AR GO:0034728 nucleosome organization 2.43e-02 2.43e-02 1 ATRX,CTCF,ARID1A,SOX9,HIST1H2BD,NPM1,SETD2 GO:0061326 renal tubule development 2.44e-02 2.44e-02 1 GATA3,SOX9,CTNNB1,WT1 REAC:69473 G2/M DNA damage checkpoint 2.54e-02 2.54e-02 1 BRCA1,TP53,ATM,HIST1H2BD,ATR,CHEK2 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2.56e-02 2.56e-02 1 STK11,ACVR2A,ACVR1B,SMAD4,NOTCH1,SMAD2 GO:0051271 negative regulation of cellular component movement 2.58e-02 2.58e-02 1 GATA3,NOTCH1,PTEN,NF1 GO:0045165 cell fate commitment 2.63e-02 2.63e-02 1 FGFR2,GATA3,SOX9,FOXA2,SOX17,SMAD2,WT1 GO:0046660 female sex differentiation 2.64e-02 2.64e-02 1 PDGFRA,TBX3,KIT,WT1 GO:1903037 regulation of leukocyte cell-cell adhesion 2.64e-02 2.64e-02 1 GATA3,PIK3CA,PIK3R1,CDKN2A GO:0090130 tissue migration 2.69e-02 2.69e-02 1 GATA3,PIK3CA,SOX9,AKT1,NOTCH1,KIT,NF1 REAC:157118 Signaling by NOTCH 2.69e-02 2.69e-02 1 EP300,FBXW7,CCND1,NCOR1,TP53,NOTCH1,TBL1XR1 GO:0008406 gonad development 2.73e-02 2.73e-02 1 GATA3,SOX9,PDGFRA,KIT,WT1 REAC:1912408 Pre-NOTCH Transcription and Translation 2.79e-02 2.79e-02 1 EP300,CCND1,TP53,NOTCH1 GO:0030168 platelet activation 2.82e-02 2.82e-02 1 PIK3CG,PIK3CA,PDGFRA,TLR4,AKT1,PIK3R1,PTPN11 GO:0072593 reactive oxygen species metabolic process 2.89e-02 2.89e-02 1 BRCA1,CDKN1A,TP53,AKT1,EGFR,TGFBR2,LRRK2 GO:0055024 regulation of cardiac muscle tissue development 2.90e-02 2.90e-02 1 FGFR2,SMAD4,NOTCH1,ERBB4 GO:0045137 development of primary sexual characteristics 2.92e-02 2.92e-02 1 GATA3,SOX9,PDGFRA,KIT,WT1 REAC:6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest 3.04e-02 3.04e-02 1 CDKN1B,CDKN1A,TP53 GO:0048872 homeostasis of number of cells 3.05e-02 3.05e-02 1 ACVR2A,FLT3,SOX9,ACVR1B,AKT1,KIT GO:1903076 regulation of protein localization to plasma membrane 3.05e-02 3.05e-02 1 AKT1,PIK3R1,EGFR,AR GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 3.07e-02 3.07e-02 1 KEAP1,FBXW7,NFE2L2,TAF1,PTEN,LRRK2,CEBPA GO:0003231 cardiac ventricle development 3.07e-02 3.07e-02 1 FGFR2,GATA3,SMAD4,NOTCH1,TGFBR2 GO:0060191 regulation of lipase activity 3.17e-02 3.17e-02 1 FGFR2,FGFR3,PDGFRA,EGFR,KIT GO:0071260 cellular response to mechanical stimulus 3.19e-02 3.19e-02 1 MAP2K4,MAP3K1,SOX9,TLR4 GO:0031668 cellular response to extracellular stimulus 3.22e-02 3.22e-02 1 CDKN1A,FOXA2,TP53,ARHGAP35,LRRK2,MTOR GO:0050851 antigen receptor-mediated signaling pathway 3.23e-02 3.23e-02 1 GATA3,PIK3CA,PIK3R1,PTEN GO:1904375 regulation of protein localization to cell periphery 3.26e-02 3.26e-02 1 AKT1,PIK3R1,EGFR,AR GO:0051148 negative regulation of muscle cell differentiation 3.26e-02 3.26e-02 1 SOX9,TBX3,SMAD4,NOTCH1 GO:0002053 positive regulation of mesenchymal cell proliferation 3.30e-02 3.30e-02 1 FGFR2,SOX9,TGFBR2 GO:0040013 negative regulation of locomotion 3.34e-02 3.34e-02 1 GATA3,NOTCH1,PTEN,NF1 REAC:202424 Downstream TCR signaling 3.34e-02 3.34e-02 1 PIK3CA,PIK3R1,PTEN GO:0007009 plasma membrane organization 3.35e-02 3.35e-02 1 CDH1,AKT1,PIK3R1,EGFR,AR,PTEN GO:0051571 positive regulation of histone H3-K4 methylation 3.37e-02 3.37e-02 1 BRCA1,SMAD4,CTNNB1 GO:1905477 positive regulation of protein localization to membrane 3.42e-02 3.42e-02 1 TP53,PIK3R1,EGFR GO:2001234 negative regulation of apoptotic signaling pathway 3.43e-02 3.43e-02 1 BRCA1,HGF,NFE2L2,AKT1,AR,LRRK2 GO:0045785 positive regulation of cell adhesion 3.46e-02 3.46e-02 1 GATA3,PIK3CA,FOXA2,FOXA1,AKT1,PIK3R1,TGFBR2,PTPN11,MTOR GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 3.49e-02 3.49e-02 1 KEAP1,NFE2L2,TAF1,LRRK2,CEBPA GO:0097194 execution phase of apoptosis 3.51e-02 3.51e-02 1 APC,TP53,CDKN2A GO:0045927 positive regulation of growth 3.58e-02 3.58e-02 1 FGFR2,AKT1,EGFR,NOTCH1,ERBB4,WT1,H3F3C GO:0006383 transcription from RNA polymerase III promoter 3.60e-02 3.60e-02 1 BRCA1,AR,MTOR,CEBPA GO:0010001 glial cell differentiation 3.60e-02 3.60e-02 1 NOTCH1,PTEN,NF1 GO:0045862 positive regulation of proteolysis 3.64e-02 3.64e-02 1 KEAP1,FBXW7,CDKN1B,NFE2L2,CDKN2A,PTEN,LRRK2,CEBPA GO:0031330 negative regulation of cellular catabolic process 3.71e-02 3.71e-02 1 HGF,PIK3CA,AKT1,TAF1,LRRK2,MTOR GO:0061217 regulation of mesonephros development 3.77e-02 3.77e-02 1 GATA3,SOX9,WT1 REAC:73894 DNA Repair 3.78e-02 3.78e-02 1 BRCA1,POLQ,EP300,BRCA2,TP53,ATM,HIST1H2BD,BAP1,ATR,CHEK2 GO:0008637 apoptotic mitochondrial changes 3.79e-02 3.79e-02 1 HGF,TP53,AKT1,CDKN2A,ERBB4 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 3.82e-02 3.82e-02 1 NFE2L2,VHL,TP53,NOTCH1 GO:0002573 myeloid leukocyte differentiation 3.82e-02 3.82e-02 1 TLR4,KIT,RUNX1,TGFBR2,MTOR,CEBPA GO:0003206 cardiac chamber morphogenesis 3.83e-02 3.83e-02 1 FGFR2,GATA3,SMAD4,NOTCH1,TGFBR2 REAC:2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer 3.86e-02 3.86e-02 1 EP300,FBXW7,NCOR1,NOTCH1,TBL1XR1 REAC:2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer 3.86e-02 3.86e-02 1 EP300,FBXW7,NCOR1,NOTCH1,TBL1XR1 REAC:2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 3.86e-02 3.86e-02 1 EP300,FBXW7,NCOR1,NOTCH1,TBL1XR1 REAC:2644603 Signaling by NOTCH1 in Cancer 3.86e-02 3.86e-02 1 EP300,FBXW7,NCOR1,NOTCH1,TBL1XR1 REAC:2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 3.86e-02 3.86e-02 1 EP300,FBXW7,NCOR1,NOTCH1,TBL1XR1 GO:0030520 intracellular estrogen receptor signaling pathway 3.93e-02 3.93e-02 1 BRCA1,ARID1A,FOXA1,CRIPAK REAC:1500931 Cell-Cell communication 4.04e-02 4.04e-02 1 CDH1,PIK3CA,PIK3R1,CTNNB1 GO:1903206 negative regulation of hydrogen peroxide-induced cell death 4.15e-02 4.15e-02 1 HGF,NFE2L2,LRRK2 GO:1901032 negative regulation of response to reactive oxygen species 4.15e-02 4.15e-02 1 HGF,NFE2L2,LRRK2 GO:1903727 positive regulation of phospholipid metabolic process 4.19e-02 4.19e-02 1 FGFR3,FLT3,PDGFRA,KIT REAC:5654727 Negative regulation of FGFR2 signaling 4.20e-02 4.20e-02 1 FGFR2,PPP2R1A,BRAF,PTPN11 REAC:75153 Apoptotic execution phase 4.34e-02 4.34e-02 1 CDH1,APC,CTNNB1 REAC:3108232 SUMO E3 ligases SUMOylate target proteins 4.35e-02 4.35e-02 1 BRCA1,SMC1A,STAG2,SMC3,TP53,CDKN2A,RAD21 GO:0007159 leukocyte cell-cell adhesion 4.39e-02 4.39e-02 1 GATA3,PIK3CA,PIK3R1,CDKN2A GO:0009612 response to mechanical stimulus 4.41e-02 4.41e-02 1 MAP2K4,MAP3K1,SOX9,TLR4,KIT REAC:5339716 Misspliced GSK3beta mutants stabilize beta-catenin 4.43e-02 4.43e-02 1 PPP2R1A,APC,CTNNB1 REAC:5358747 S33 mutants of beta-catenin aren't phosphorylated 4.43e-02 4.43e-02 1 PPP2R1A,APC,CTNNB1 REAC:5358751 S45 mutants of beta-catenin aren't phosphorylated 4.43e-02 4.43e-02 1 PPP2R1A,APC,CTNNB1 REAC:5358752 T41 mutants of beta-catenin aren't phosphorylated 4.43e-02 4.43e-02 1 PPP2R1A,APC,CTNNB1 REAC:4839743 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex 4.43e-02 4.43e-02 1 PPP2R1A,APC,CTNNB1 REAC:5358749 S37 mutants of beta-catenin aren't phosphorylated 4.43e-02 4.43e-02 1 PPP2R1A,APC,CTNNB1 REAC:5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 4.51e-02 4.51e-02 1 EP300,CTCF,EZH2,AJUBA,NCOR1,KDM6A,HIST1H2BD REAC:5619507 Activation of HOX genes during differentiation 4.51e-02 4.51e-02 1 EP300,CTCF,EZH2,AJUBA,NCOR1,KDM6A,HIST1H2BD GO:0033047 regulation of mitotic sister chromatid segregation 4.53e-02 4.53e-02 1 ATRX,APC,RB1,ATM GO:0072006 nephron development 4.53e-02 4.53e-02 1 GATA3,SOX9,PDGFRA,CTNNB1,WT1 GO:0006323 DNA packaging 4.55e-02 4.55e-02 1 ATRX,CTCF,SOX9,TP53,CDKN2A,NPM1 GO:0043620 regulation of DNA-templated transcription in response to stress 4.56e-02 4.56e-02 1 NFE2L2,VHL,TP53,NOTCH1 GO:0050870 positive regulation of T cell activation 4.66e-02 4.66e-02 1 GATA3,PIK3CA,AKT1,PIK3R1,TGFBR2,PTPN11,MTOR GO:0050890 cognition 4.71e-02 4.71e-02 1 EGFR,PTEN,NF1 GO:0071241 cellular response to inorganic substance 4.77e-02 4.77e-02 1 CDH1,ATRX,CDKN1B,BRAF,LRRK2 GO:0010035 response to inorganic substance 4.92e-02 4.92e-02 1 HGF,CDH1,ATRX,CDKN1B,NFE2L2,BRAF,LRRK2 GO:0031589 cell-substrate adhesion 4.95e-02 4.95e-02 1 CDKN2A,NOTCH1,PTEN,NF1 GO:0006984 ER-nucleus signaling pathway 4.95e-02 4.95e-02 1 FBXW7,NFE2L2,TP53